Articles

Intraductal Papillary Neoplasm of Bile Ducts: Report of Two Cases

Case Series   Open Access
IPNB is a rare neoplasia (10-15% of the overall biliary neoplasms), which is a close mimicker as well as precursor of intraductal cholangiocarcinoma. A significant number of patients remain asymptomatic and the disease is incidentally detected during evaluation for unrelated symptoms.

Unveiling the Link to ABC Proteins and Epithelial-Mesenchymal Transition in Cancer

Review Article   Open Access
Cancer is a major global health issue, being the second leading cause of death. Amongst the characteristics observed in cancer cells that contribute for tumor progression and poor prognosis are the acquisition of the Multi-Drug Resistance (MDR) phenotype and the induction of metastasis.

Quality of Life, Independence, Support in Patients Before and After Surgery with Head Cancer

Research Article   Open Access
All over the world we are seeing an increase in cases of head cancer, which affects the quality of life and independence. If we know the health problems before and after surgery, we know that there are headaches, aphasia, epileptic seizures, limb paresis, affecting self-reliance or quality of life.

The Relationship of Molecular Subtypes to Breast Cancer Survival in Arifin Achmad Pekanbaru Hospital, 2014-2023

Research Article   Open Access
Breast cancer is a malignancy of breast tissue originating from the ductal epithelium or its lobules. Its study aims to know characteristics among breast cancer patients in Arifin Achmad hospital from 2017 to 2021.

A Rare Case of Intracranial Germ Cell Tumor in the Elderly: A Case Report

Case Report   Open Access
The vast majority of Germ Cell Tumors (GCT) derive from within the gonads, but a small percentage can arise from extragonadal tissue and are therefore called Extragonadal Germ Cell Tumors (EGCTs) [1]. We report a case of a 74-year-old man with a rapidly developing loss of memory.

DNA Copy Number Variation of Sox4 Fail to Maintain Pluripotency Results to Promote Metastasis in Breast Cancer Patients

Research Article   Open Access
Sox4, early transcription factor and is play an important role during movement of epithelial to mesenchymal transition through invasion and followed by initiation of tumor progression in Breast Cancer (BC) patients. Genetic diversity of stem cell are the unique phenomenon and has been associated with epigenetic modification.

Dynamic Expression Profiles of HMGB1 after BNCT and γ-Irradiation in Cancer Cells

Research Article   Open Access
HMGB1 is known as a DNA-binding protein and present in nucleus. It is involved in chromatin and transcriptional regulation. We previously observed extracellular release of HMGB1 occurs as early responses from cancer cells after Boron Neutron Capture Therapy (BNCT) following 10B-Boronophenylalanine (BPA) administration.

Advanced Life Support in Oncology Intensive Care Units: A Prospective Observational Study

Research Article   Open Access
The survival rate of cancer patients has increased in recent decades, leading to a growing number of admissions to Intensive Care Units (ICUs) and artificial life support, often with questionable indications.

Preservation of Fertility in Patients with Breast Cancer: Literature Review

Review Article   Open Access
Oncofertility is a discipline about the possibility of maintaining reproductive function in patients with malignant tumors. This new medical discipline is based on two main principles – safety and efficiency.

Assessment of Cytotoxicity and Cytokine Expression Pattern of HepG2 Cell Line by Ultra Diluted Hydrastis Canadensis

Research Article   Open Access
The incidence of liver cancer, especially hepatocellular carcinoma, has been increasing at an alarming rate worldwide, which is characterized by poor prognosis, and the treatment of advanced cases is extremely difficult.

Role of Cancer Stem Cells in Failure of T Cell Immunotherapy

Review Article   Open Access
Over the past decade, immunotherapy has emerged as one of the most promising approaches to cancer treatment. Immunotherapy employing Immune-Checkpoint Inhibitors (ICIs), Adoptive Cell Transfer (ACT), Chimeric Antigen Receptor (CAR) - engineered T cells and cancer vaccines, have generated encouraging responses in the treatment of various cancers, and effector anti-tumor T cells.

Comprehensive Analysis Reveals Genomics and Clinical Characteristics of the DNMT Family and TET Enzyme Family in Pan-Cancer

Research Article   Open Access
The purpose of this study is to comprehensively analyse the specific roles of DNA Methyltransferase (DNMT)/Ten-Eleven-Translocation (TET) family genes in pan-cancer. The expression, mutation, Copy Number Variations (CNVs), cancer-related pathways, immune cell infiltration correlation and prognostic potential of DNMT/TET genes were systematically investigated in 33 cancer types using next-generation sequencing data from The Cancer Genome Atlas database.

Molecular Identification and Successful Treatment with Targeted Therapy in Gorlin Syndrome: A Case Report

Case Report   Open Access
Gorlin Syndrome (GS), is a rare autosomal dominant cancer predisposition disorder, frequently under-diagnosed. It is characterized by the presence of multiple Basal Cell Carcinomas (BCCs), odontogenic keratocysts, palmoplantar pits, and many other developmental anomalies and neoplasms.

Resection of Isolated Bilateral Adrenal Metastases from Colorectal Adenocarcinoma

Case Report   Open Access
Bilateral adrenal metastases from colorectal cancer with no extra-adrenal signs of disease is a very rare clinical entity with no established guidelines for management. We describe the unusual clinical treatment course of a 73-year-old male who developed isolated bilateral adrenal metastases within 3 years after resection of a primary rectal adenocarcinoma.

Clinical Case Data Review and Literature Review of Breast Lymphoma

Research Article   Open Access
To investigate the clinical, and pathological features, diagnosis, treatment, and prognosis of Breast Lymphoma (BL). Methods: The general case data of 16 inpatients with breast lymphoma admitted to Liaoning Cancer Hospital from 2014 to 2022 were retrospectively analyzed, and their disease characteristics, treatment and prognosis were analyzed.

Identification of the IncRNA HIF1A-AS3 Biomarker and Analysis of Immune Infiltrates in Breast Cancer

Research Article   Open Access
Breast Cancer (BC) is the predominant malignant tumor among women globally. It has high recurrence which have adverse effects on patient outcomes. Therefore, there is need to identify effective biomarkers for prognostic evaluation.

Artificial Nutrition in Patients undergoing Cytoreductive Surgery and HIPEC

Short Commentary   Open Access
Nutrition's impact on the surgical outcome has been established in various surgical specialties. However, data addressing the nutritional considerations following Cytoreductive Surgery (CRS) and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) are scarce. We present our experience in nutritional management in our patients underwent CRS+HIPEC.

Unveiling the Promise of Cancer Neoantigens: A New Frontier in Immunotherapy

Review Article   Open Access
Cancer is not only one of the leading causes of mortality and morbidity worldwide, but it is also a large economic burden on the world's population. Tumour heterogeneity restricts the concept of a single drug that can be universally effective against all cancer types.

Development of an Information-Gathering Tool to Support Work Continuity in Cancer Patients Undergoing Outpatient Radiation Therapy

Research Article   Open Access
This study aimed to develop an information-gathering tool to assist cancer patients undergoing outpatient radiation therapy. The tool was designed to help patients and nurses assess symptom management, anticipate treatment-related reactions and social factors, identify concerns early, and support patients in balancing work and treatment.

Recent Advances in Interventional Therapy for Hepatocellular Carcinoma

Review Article   Open Access
Hepatocellular Carcinoma (HCC) is one of the most prevalent and lethal cancers globally. Early diagnosis remains challenging due to the disease's subtle symptoms, often leading to detection at advanced stages with limited treatment options and poor outcomes.

Benefit of Adjuvant Radiotherapy in Parotid Cancer: Single Center Experience

Research Article   Open Access
Observe the benefit of adjuvant radiotherapy in parotid cancer patients in 2 years, regarding the local control and identifying factors of recurrence. The selection of patients was in the Oncology Hospital, XXI Century National Medical in Mexico. The period was from 2013 to 2018, reviewing 129 expedients of patients with parotid cancer who received radiotherapy, finding 52 patients to evaluation for the study.

Audit on the Incidence of Malnutrition in Oncology Patients in South Tipperary General Hospital (STGH)

Short Commentary   Open Access
To first define a cancer patient, a cancer patient is a person who has received a cancer diagnosis who is: going to start treatment or receiving treatment for cancer or symptom management and/ or receiving palliative care [1].

KISS1R Antagonism as a Promising Anti-Cancer Approach: An Overview on Function, Molecular Mechanisms and Therapeutic Potential

Review Article   Open Access
Herein, we explore the Kisspeptin 1 Receptor (KISS1R) as a potential therapeutic target for the restoration of drug sensitivity in Triple-Negative Breast Cancer (TNBC) clinical settings. Recent functional studies of KISS1R have revealed that the receptor plays a pro-metastatic role in TNBC.

Sequential Lineage Switch from B-ALL to AML to MPAL in an Elderly Patient with KMT2A/AFF1 Fusion

Case Report   Open Access
Lineage switch in acute leukemia is rare, often seen in infants and pediatric patients during or after therapy. This report details a unique case in an elderly individual initially diagnosed with Acute B-Lymphoblastic Leukemia (B-ALL) featuring KMT2A/AFF1.

Male Primary Pulmonary Choriocarcinoma with SMARCA4 Deficiency: A Case Report and Literature Review

Case Report   Open Access
We report a rare case of primary pulmonary choriocarcinoma with SMARCA4 deficiency. The patient, a 54-year-old male, had a lesion in the upper lobe of the left lung, identified during a routine physical examination. Pathological examination of the resected specimen revealed a 5.0 cm x 4.5 cm x 3.0 cm tumor.

Impact of the Methodology of Breast Cancer Screening Camps: A Community Based Observational Study

Research Article   Open Access
Breast cancer is a significant health concern globally and early detection remains pivotal for effective treatment. In resource-constrained settings such as India, innovative screening approaches are crucial. This study examines the impact of community-based screening camps versus hospital-based screening within a district-level hospital context, considering accessibility and outreach.

Risk and Predictive Factors of Rate of Lymph Node Invasion in Breast Cancer with Axillary Involvement

Research Article   Open Access
Breast cancer is the most common cancer among women in France. Axillary lymph node invasion has a major prognostic impact. The aim of this study was to evaluate the risk and predictive factors of the rate of lymph node invasion in breast cancer with axillary involvement.

Role of Androgen Receptor in Prostate Cancer: A Brief Update

Review Article   Open Access
Androgen Receptor (AR) is a transcription factor for testosterone and dihydrotestosterone. Prostate cancer cells' survival, growth, and proliferative activity highly depend on a functional AR. The androgen receptor gene is located on chromosome X (Xq11-12) and encodes a 919 amino acid protein with four domains.

Synthesis, Characterization, and Anticancer Activity Studies of the Novel Pyridinyl Zn (II) and Ni (II) Metal Complexes

Research Article   Open Access
Cancer is regarded as one of the «three major killers» threatening human health, and for many years, countless researchers have devoted themselves to researching anticancer agents in the hope of improving the survival rates of cancer patients.

The Importance of Biliary Drainage Catheter Diameter in Malignant Stricture

Research Article   Open Access
Efficacy of 8F and 10F biliary drainage catheters compared in patients with malignant stenosis. Between 2010 and 2012, 106 patients presenting to interventional radiology for malignant biliary obstruction were assessed and 54 patients were included in the study. Liver function tests.

How important is early Disease Detection through Regular Systematic Examinations in People older than 65 Years: An Example of Two Cases

Case Report   Open Access
Early detection of cancer in people over the age of 65 is a key aspect in the fight against this vicious disease. Aging of the body carries with it a number of changes that increase the susceptibility to developing cancer, with greater exposure to risk factors throughout the lifespan.

Primary Frontal Sinus Carcinoma: A Case Report

Case Report   Open Access
Primary frontal sinus carcinoma is rare, with an incidence of 0.3-1% of all paranasal sinus carcinomas. We present an 84-year-old woman who, about a month ago, developed erythema and edema of the skin of the upper eyelids and glabella, accompanied by eye discharge and slight tenderness to touch.

Environmental and Ingestible Toxins: A Review of their Role in the Development of Colon and Rectal Cancer

Review Article   Open Access
In this paper, we review the epidemiological evidence on the relationship between environmental and ingestible toxins and colorectal cancer. We searched PubMed, Embase, and Web of Science for epidemiological studies on environmental and ingestible toxins and colorectal cancer published before June 1, 2022.

Medical Aid in Dying in Pakistan

Mini Review   Open Access
Medical Aid in Dying, or Physician Assisted Suicide, is the practice of hastening the death of those suffering from an incurable disease, such as cancer, or a debilitating disorder, such as amyotrophic lateral sclerosis. It is a practice that is gaining acceptance in many countries around the world.

Efficacy and Safety of Shen Fu Injection Alleviating Chemotherapy-Induced Peripheral Neurotoxicity: A Randomized Controlled Trial

Research Article   Open Access
To analyze the effect of Shenfu injection on Chemotherapy-Induced Peripheral Neuropathy (CIPN) at different stages of tumor chemotherapy. An analysis of 153 patients who were divided into chemotherapy group and combined group was performed chemotherapy within two to six cycles with oxaliplatin or paclitaxel, and combined with or without Shenfu injection.

Recent Advances in Gastrointestinal Neuroendocrine Tumor Classification

Review Article   Open Access
Gastrointestinal Neuroendocrine Tumors (GI-NETs) encompass a broad spectrum of neoplasms arising from neuroendocrine cells, showcasing diverse clinical manifestations and behaviors. The evolution of GI-NET classification has been marked by advancements in histopathology, molecular biology, imaging, and biomarker discovery.

Reversible Toxic Encephalopathy related to Treatment with Capecitabine: A Discussion about Chemotherapy-Induced Neurotoxicity and a Case Report

Case Report   Open Access
Capecitabine is a chemotherapeutic widely used in current medical practice, quickly replacing 5-Fluorouracil in the treatment of certain cancers. Although it is rarely encountered, neurotoxicity is an adverse effect that should not be neglected, especially if elderly patients are involved.

Efficacy of Traditional Chinese Medicine Treatment alone for Recurrent and Refractory Castration-Resistant Prostate Cancer: A Case Report and Literature Review

Case Report   Open Access
Prostate Cancer (PCa) is a malignant tumor that occurs in the epithelial gland of prostate, and it ranks 6th in the incidence rate of malignant tumors among men in China, while the death rate ranks 2nd. The probability of distant metastasis can be as 30 high as 70%, with bone metastasis being the most common.

Thymic Epithelial Tumour Size Reduction after Steroid Therapy without Chemotherapy: A Possible Tumour Treatment? Case Report and Literature Review

Case Report   Open Access
Myasthenia Gravis (MG) is a neuromuscular junction disorder characterised by antibodies directed against postsynaptic antigens (mainly the Acetylcholine Receptors (AChR)). The management of MG symptoms relies on the utilization of anticholinesterases (such as Pyridostigmine), immunosuppressive and immunomodulatory therapies, including therapeutic plasmapheresis or high-dose human immunoglobulin.

Computer-Aided Diagnosis System Based on Deep Learning for Diagnosis of Atypical Endometrial Hyperplasia and Endometrial Cancer on Hysteroscopy

Research Article   Open Access
Hysteroscopy is an effective tool to diagnose and treat abnormal uterine bleeding or uterine cavity abnormalities, especially precancerous or cancerous disorders. In this study, we proposed an Endometrial Cancer (EC) Computer-Aided Diagnosis System (ECCADx) based on deep learning to boost the diagnostic accuracy.

Isolated Breast Sarcoidosis

Case Report   Open Access
Sarcoidosis is a rare non-caseating granulomatous disease of unknown origin that affects multiple systems in the body occurring more frequently in young women age 17-24 years.

RAD6 Overexpression and Ovarian Cancer Chemo-Resistance: Flow Cytometry and Immunohistochemistry

Research Article   Open Access
Ovarian cancer is one of the deadliest women's cancers in the world. Nearly all the patients have poor prognosis and recurrence after standard therapy because of chemo-resistance. The standard therapy is cytoreductive debulking surgery followed by platinum-based chemotherapy.

Oral Tissue Lesions Manifestation in Cancer Patients Following Chemotherapy and Head and Neck Radiation Therapy

Review Article   Open Access
As is known, cancer therapy includes a complex of therapeutic measures: chemotherapy, radiotherapy and radical. The purpose of this study was to review the literature on the main oral tissue complications arising from chemotherapy and radiation therapy in the head and neck region.

A Simplified Approach for Evaluation and Management of Thyroid Incidentalomas

Review Article   Open Access
The incidence of thyroid nodules has become exceedingly common seen in as many as one in seven adults owing to the increased detection through routine imaging studies. These are called incidental thyroid nodules or incidentalomas, many of which are occult differentiated micro carcinomas.

Elucidating the Role of Malnutrition in Acute Leukemia Patients and How it Leads to Adverse Events During Hospitalization: An Interesting Study

Research Article   Open Access
Malnutrition negatively impacts patients with hematologic malignancies and is considered a poor marker and indicator of prognosis. Our study explored the association between malnutrition and patients hospitalized with acute leukemia, including patients with both acute myeloid and acute lymphocytic leukemia.

Comparative Analysis of Enteral and Parenteral Nutrition Impact on Outcomes in Esophageal Cancer Patients: A Paradigm for Nutritional Optimization in Oncology

Research Article   Open Access
Individuals diagnosed with esophageal cancer face a pronounced risk of malnutrition, primarily attributed to the early onset of gastrointestinal obstruction. This risk persists and may even intensify following therapeutic interventions and the subsequent reconstruction of gastrointestinal passages. The current study focuses on elucidating the differential impact of enteral vs. parenteral nutrition on outcomes in patients hospitalized with esophageal cancer.

Revealing the Correlation Between Multiple Myeloma and Frailty: Contemporary Perspectives and In-Depth Insights

Research Article   Open Access
The research sought to assess the association between frailty and hospitalized individuals with a diagnosis of multiple myeloma. The National Inpatient Sample database for 2019-2020 was queried to identify individuals over 18 years diagnosed with multiple myeloma, utilizing the appropriate ICD-10 codes.

Hepatocellular Carcinoma with Portal Vein Thrombus has Achieved Complete Remission by Hepatic Arterial Infusion Chemotherapy Combined with Anti-PD-1 Therapy: A Case Report

Case Report   Open Access
A 56-year-old female was diagnosed with advanced hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT) in December 15, 2021. Half a month after oral sorafenib treatment, the patient experienced hematemesis and systemic rash reactions and was admitted to our hospital. An abdominal MRI revealed an 8.6 cm mass in the right lobe of the liver with PVTT.

Resection of a Gastroblastoma in an Adult Patient: An Unsuspected and Unusual Tumor

Case Report   Open Access
Since the first description of gastroblastoma in 2009, 19 cases have been previously reported, most of them in young adults and children. The prognosis is uncertain, however, malignant tumors have been described. A female patient, 44-years-old was studied with upper endoscopy and abdominal tomography for an incidentally found, submucosal tumor of the gastric antrum.

Empowering Oncologists to Successfully Address Non-Medical Opioid Use During Cancer Treatment: A Review of Best Practices

Review Article   Open Access
Non-medical opioid use (NMOU), opioid use disorder (OUD) and substance use disorders (SUD) in patients with cancer present an ongoing and growing challenge to the teams caring for them, especially their most trusted partners, oncologists.

Adult Intradural Extramedullary Ewing's Sarcoma of the Lumbar Spine and Involving the Intervertebral Foramen: A Case Report

Case Report   Open Access
Spinal intradural extramedullary Ewing's sarcoma (IEES) is very rare. Here, we report an adult IEES located in the lumbar spine and involving the intervertebral foramen. A 45-year-old gentleman presented with a one-month history of low back pain. The magnetic resonance imaging (MRI) and computed tomography (CT) showed occupation of the spinal canal and right intervertebral foramen at L4-5 levels.

The Effects of Calcium Channel Blocker Combined with Oxaliplatin on Apoptosis of Bladder Cancer Cells

Research Article   Open Access
This experiment explores the effect of calcium ion (Ca2+) on oxaliplatin-induced bladder cancer cell apoptosis and investigates the impact of blocking calcium channels on oxaliplatin-induced bladder cancer cell apoptosis. Bladder cancer cells were cultured in vitro.

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